Kerio MailServer runs on the application layer and there are not any known low-level conflicts with other software, operating system components or device drivers (except the antivirus that is used to open files). If a received email message includes an infected attachment, the mail server stores it into a temporary file on the disk. Antivirus might damage the disk or the system. To prevent your computer from such failure, configure your antivirus to not scan the folder (or the disk) where Kerio MailServer data is kept (refer to chapter 14 Antivirus Control of Email And Attachment Filtering).
A possible conflict is a port clash (if all services are running in Kerio MailServer, these TCP ports are used: 25, 80, 110, 119, 143, 443, 465, 563, 993 and 995). It is therefore not recommended that users run other mail, LDAP or web server software on the same computer. If this is necessary, the system administrator must ascertain that there will be no port clashes. For example, if Kerio MailServer is running on a computer together with a web server, we recommend changing the HTTP service port or disabling the service and only enabling its secured version — Secure HTTP. Another alternative is to reserve one or more IP addresses for ports at which Kerio MailServer services are listening. For detailed information on services and port settings, see chapter 6 Services.
If Kerio MailServer is run on a firewall or on a secured local network behind a firewall, the firewall will affect the mail server's behavior to a certain extent (e.g. accessibility of some or all services). When configuring the firewall take into consideration which services should be accessible from the Internet or the local network and enable communication on appropriate ports (see above or chapters 6 Services and 29.3 Firewall for more detail).